FIP1L1/RARA with breakpoint at FIP1L1 intron 13: a variant translocation in acute promyelocytic leukemia.

نویسندگان

  • Juliane Menezes
  • Francesco Acquadro
  • Concepción Perez-Pons de la Villa
  • Félix García-Sánchez
  • Sara Álvarez
  • Juan C Cigudosa
چکیده

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منابع مشابه

Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromosomal translocations in acute promyelocytic leukemia

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromo-somal translocations in acute promyelocytic leukemia TO THE EDITOR: We read an interesting paper by Palta et al. in a recent issue of the Korean Journal of Hematology tit...

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Early discharge from hospital after consolidation chemotherapy in acute myeloid leukemia in remission: febrile neutropenic episodes and their outcome in a resource poor setting.

1. Zelent A, Guidez F, Melnick A, Waxman S, Licht JD. Translocations of the RARα gene in acute promyelocytic leukemia. Oncogene 2001;20:7186-203. 2. Catalano A, Dawson MA, Somana K, Opat S, Schwarer A, Campbell LJ, et al. The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia. Blood 2007;110:4073-6. 3. Kwok C, Zeisig BB, Dong S, So CW. Forced homooligomerization of RARα...

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Cytogenetic and FMS-Like Tyrosine Kinase 3 Mutation Analyses in Acute Promyelocytic Leukemia Patients

Background: The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutat...

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RAPID COMMUNICATION The t(15;17) Breakpoint in Acute Promyelocytic Leukemia Cluster Within Two Different Sites of the myl Gene: Targets for the Detection of Minimal Residual Disease by the Polymerase Chain Reaction

The retinoic acid receptor a (RARa) and the my1 gene are involved in the translocation breakpoint t(15;17)(q22;q21) in acute promyelocytic leukemia (APL). The majority of the breakpoint sites have been mapped within the second intron of the RARa gene; however, the breakpoint sites on the my1 gene are variable. Using primer sets derived from exon 2 or exon 3 of the RARa gene and a primer derived...

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Coexistence of t(15;17) and t(15;16;17) detected by fluorescence in situ hybridization in a patient with acute promyelocytic leukemia: A case report and literature review

Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The current study presents the case of a 54-year-old female with APL carrying the atypical PML/RARA fusion signal due to a novel complex variant translocation t(15;16;17)(q22;q24;q21), ...

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عنوان ژورنال:
  • Haematologica

دوره 96 10  شماره 

صفحات  -

تاریخ انتشار 2011